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Alternatively, this could be called stage 0, as there are no manifestations of disease at this point

"If you ignore something like that, that's going to send a horrendous message through the rest of the ranks

The historical perspective Initial clinical findings that the intestinal epithelium of IBD patients is more permeable to tracer molecules known to permeate through the paracellular space 28, 29, 30, 31 led to the hypothesis that an uncontrolled mucosal barrier may help promote IBD pathogenesis