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A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

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Consistent with the prodifferentiation effects of ENL inhibitors and degraders on leukemia cells 54,57,58 , we also noted an increase in transcription of the myeloid differentiation marker ITGAM (encoding CD11b), which was confirmed by measuring cell surface expression of CD11b in the spleen and peripheral blood (Fig