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However, contrasting results have also been reported documenting no changes in the Firmicutes/Bacteroidetes ratio in gut microbiota of rats and mice exposed to AgNPs at dose levels of 9 mg/kg bw/day and 10 mg/kg bw/day, respectively (Wilding et al., 2016

Activated T cells undergo significant metabolic shifts that depend on glucose catabolism 38,39,40,41

This may improve its stability and support healthy glutathione levels within the body

In conclusion, activating the Nrf2 pathway is like building a comprehensive shield, which directly strengthens the defense capability of GPX4 on the one hand, and maintains the iron balance on the other hand, thus effectively stopping the ferroptosis process