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Similar to insulin, IGF-I appears to stimulate klotho secretion (22, 100), whereas klotho inhibits insulin/IGF-I signaling (101) ( Figure 7 ), and activation of both hormone receptors (101)

Their small size, rapid development, and genetic tractability make them ideal organisms for investigating the underlying mechanisms of oxidative stress and developing new treatments to mitigate its negative climatic impacts (Villamizar et al., 2014