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Harmful Contaminants: Leftover solvents, heavy metals, or byproducts from sloppy synthesis can be present

Higher amounts were not better: across trials, 1 mg and 2 mg three times daily and the 1/4/8 mg doses used in gluten-challenge studies did not outperform 0.5 mg, an atypical pattern researchers attribute to a surface-acting agent whose luminal effect may be self-limiting at higher concentrations [2] [5]