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A high CTR1 level is regarded as a predictor of prolonged survival and enhanced response to chemotherapy in cancer patients [9]

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For instance, a patient genetically predisposed to low CYP2C19 activity (poor metabolizer phenotype) and carrying the 5-HTTLPR S allele may experience higher systemic drug exposure yet diminished pharmacodynamic response at the receptor level, underscoring the multifactorial nature of antidepressant outcomes (Table 2) ( TABLE 2 Summary of key pharmacogenetic recommendations and indicative strength of evidence

Nevertheless, the potential mechanism of DON-induced ovary damage in pigs has not been fully clarified