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MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers

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that oxidation of Cys residues in STAT3 into disulfide(s) would block its activation, but our findings clearly suggested that STAT3 function is fully TrxR1-dependent

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Chen Y-Y, Chen C-K, Wu T-T, Ho C-Y, Yeh T-C, Sun G-C, et al

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