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Transitioning from these cellular findings to the robust identification of these circulating oxidized byproducts (such as 4-HNE, specific epoxy-derivatives, or altered ceramide ratios) in the bloodstream will solve two problems at once: providing a reliable, non-invasive tool to monitor FRDA progression and offering definitive proof of target engagement when testing new anti-ferroptotic drugs

Mitochondrial transformation of mammalian cells

The study also noted reduced liver fat, as measured by the controlled attenuation parameter (CAP), pointing to a potential reduction in steatosis severity

, 8 , 5074, doi: Lo, M., Wang, Y