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Since ABCB7 shares 42% and 29% sequence identity, respectively, with these transporters, we hypothesized that it might similarly mediate the active transport of porphyrins from the mitochondrial matrix to the intermembrane space (Supplementary Fig 1)

Its levels gradually decline with age, correlating with increased mitochondrial oxidative damage

Exposure to UV light and atmospheric oxygen generates reactive oxidative species that convert tryptophan's indole ring into oxidized products (kynurenine pathway derivatives and others)

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