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Finally, a large meta-analysis including 38 randomized controlled trials showed no significant difference in risk of major adverse cardiovascular events (myocardial infarction, cerebrovascular accident, or cardiovascular death) in patients with psoriasis ( n = 18,024) treated with biologic therapies including anti-IL-12/23, TNF- inhibitors, and anti-IL-17A agents (118)

Reference lists were also screened to identify further eligible studies

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Contraindications Contraindications for this combination are the individual contraindications of each compound: GHK-Cu should be avoided if you have: Wilson's disease or other copper metabolism disorders Known allergy to copper or copper peptides Semaglutide should be avoided if you have: Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 Active or recent pancreatitis Pregnancy or breastfeeding Monitoring Recommendations For patients using GHK-Cu alongside semaglutide, we recommend: Standard semaglutide monitoring (metabolic panel, HbA1c, lipids at baseline and periodically) Copper and ceruloplasmin levels at baseline if there's any concern about copper metabolism Skin assessment at each follow-up to evaluate tissue response General nutritional assessment to ensure adequate micronutrient intake Monitoring and lab work Frequently Asked Questions Can GHK-Cu cause copper toxicity when used with semaglutide