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They are formed when lymphocytes circulate through the thymus gland and differentiate to thymocytes

The medial prefrontal cortex (mPFC), which can be subdivided into the prelimbic (PL) and infralimbic (IL) cortices is essential for higher-order cognitive functions such as decision-making, working memory, and behavioral regulation [20]

This is associated with an inflammatory phenotype and can promote neurodegeneration

10.19540/j.cnki.cjcmm.2017.0153 Summary Keywords rheumatoid arthritis, total glucosides of paeony, collagen-induced arthritis, metabolomics, network pharmacology, intestinal mucosal immunity Citation Xu R, Peng J, Ma Z, Xie K, Li M, Wang Q, Guo X, Nan N, Wang S, Li J, Xu J and Gong M (2023) Prolonged administration of total glucosides of paeony improves intestinal immune imbalance and epithelial barrier damage in collagen-induced arthritis rats based on metabolomics-network pharmacology integrated analysis