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For instance, pretreatment of AC16 cardiomyocytes with NaHS could retard palmitic acid-induced cardiac lipotoxicity and apoptosis, which is similar to the effects of an endoplasmic reticulum stress inhibitor 4-phenylbutyric acid ( 2 S suppresses diabetes-induced endoplasmic reticulum stress and abrogates myocardial hypertrophy and myocardial collagen deposition in diabetic rats (Li et al., 2016)