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We used ADAM optimizer with learning rate 0.001 and exponential learning rate decay 0.98 every 10,000 steps

While surgical denervation does not adversely affect expression of Mist1 (Fig 3B and E), muscarinic stimulation is sufficient to increase MIST1 in human cultures and suggests that although not required for acinar cell identity, acetylcholine/muscarinic signaling may act as a positive regulator of the secretory program

Confirm the volume in the syringe barrel before proceeding

Mitochondrial DNA damage and copy number We assessed mitochondrial DNA copy number (mtDNA CN) and mitochondrial DNA damage (mtDNA damage) as follows