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In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation

Rijhsinghani K., Krakower C., Swerdlow M., Abrahams C., Ghose T

Insulin promotes sugar absorption by cells, stores sugar as glycogen, encourages fat storage, and signals the body to develop skeletal muscle

For example, Metabolon, a major commercial provider of metabolomics services widely used in the United States, employs a general metabolite panel and a more specific lipid-focused panel, which can lead to inconsistencies when comparing results across different platforms or timeframes (Germain et al., 2020)