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To confirm this finding, we selected tubular ER markers based on published RNA sequencing data (Supplementary Fig 1c) and conducted immunohistochemistry on spinal cord cross-sections from P14 mice

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Significantly, enhanced transamination and aspartate synthesis in K-Ras-driven cancer cells are important in the promotion of nucleotide biosynthesis 184 and maintenance of redox balance 29

For example, in glutamine-addicted clear cell renal cell carcinomas, the competitive consumption of glutamine by tumor cells results in local deprivation of extracellular glutamine, which activates HIF-1 and induces tumor-infiltrating macrophages to secrete IL-23