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Evidence (excision): A randomized trial compared narrow margins (1 cm) with wide margins (3 cm) in 612 patients with melanomas no thicker than 2 mm.[1,2][Level of evidence A1] No difference was observed between the two groups in the development of metastatic disease, disease-free survival (DFS), or overall survival (OS)

Oscar Lambret Center, Lille

For a 0.5mg dose: 0.5 5 = 0.1mL, which equals 10 units on a U-100 insulin syringe

MT-1 in subcutaneous implant formulation and documented significant increases in pain-free sun exposure time in EPP patients, with studies characterising reduced phototoxic reactions, improved quality of life, and clinically meaningful photoprotection in a patient population where even brief visible light exposure produces severe phototoxic pain