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1 Vitamin D exerts its biological actions through vitamin D receptors and hence plays its role through the regulation of gene expression in places where its receptors exist, such as the endocrine system

There is a large microbial community in the human gut, and at least 20% of small molecules in the human blood are products of the microbiome, which plays a vital role in our physiology and metabolism (Rook et al., 2017)

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However, with long-acting GLP-1 RAs, the body may develop tolerance (tachyphylaxis) to this specific effect over time (Dungan & DeSantis, 2026)