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"Because oxidative stress is a primary factor for tissue damage in every organ, pharmacologically driving the antioxidative response system by Nrf2 activators is plausible for curing a variety of diseases." - Source

Lokugamage MP, Vanover D, Beyersdorf J, et al

Authoritative guidance notes the adult RDA is 2.4 mcg/day and that people over 50 often benefit from fortified foods or supplements to meet needs ( Dietary Reference Intakes )