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Cold Spring Harb Perspect Biol (2014) 6:a016295

5.4 New Treatment Approches for DPN Recent advancements in DPN treatment focus on both symptom management and addressing underlying nerve damage through innovative pharmacological, non-invasive and regenerative approaches

MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Mild injection-site reactions Transient hunger (mild) Rare water retention Rare mild flushing Known interactions Concurrent rhGH not recommended Insulin / glucose-lowering agents (mild hyperglycemia possible) Contraindications Active malignancy Pituitary tumor Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Not FDA-approved

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