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The upregulation of miR-21 in macrophages, the key cells of the inflammatory response in MASLD, has been associated with a systemic inflammatory response and increased production of proinflammatory cytokines such as IL-1, TNF, and IL-6 [311]

Chem Rev 59:583628 Rajasekaran NS, Varadharaj S, Khanderao GD, Davidson CJ, Kannan S, Firpo MA, Zweier JL, Benjamin IJ (2011) Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice

5: Astaxanthin and Vitamin E

109 Pulcinelli et al 303 revealed that increased COX-1 sensitivity and TXB2 production in diabetic patients might be responsible for the decreases in cardiovascular benefits from chronic aspirin treatment compared with those in nondiabetic patients