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The enzyme AGAT utilizes L-Arg and Gly to produce guanidinoacetate, which is further metabolized to form creatine

While the regulation of mTORC1 is well-characterized, less is known about the modulators of mTORC2 signaling

In addition, this pathway indirectly modulates responses to immunotherapy by remodeling the tumor microenvironment, promoting infiltration of tumor-associated macrophages and upregulating immune checkpoint molecules such as PD-L1) (275)