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Bartke A, Chandrashekar V, Dominici F, Turyn D, Kinney B, Steger R, Kopchick JJ: Insulin-like growth factor 1 (IGF-1) and aging: controversies and new insights

Moreover, many studies have shown a clear connection between IGF-1 deficiency and metabolic syndrome

In the context of liver-adipose tissue axis, elevated lipin-1 levels aggravate abnormal iron deposition and increases hepatic MDA levels in GPx4-independent manner, thereby aggravating alcoholic steatohepatitis and hepatobiliary injury [193]