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Its relevance to exercise and aging has recently attracted attention, as glycine availability declines with age, potentially contributing to impaired muscle repair, reduced metabolic flexibility, and increased oxidative stress ( Clinical studies examining direct supplementation are limited, but glycine's involvement in glutathione synthesis suggests a protective effect against exercise-induced oxidative stress

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However, ablation of VEGFR-1 signaling can reverse the abnormal TME associated with obesity and reprogram TAMs to promote their acquisition of the M1 phenotype