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Indeed, mucosal GSH depletion for a prolonged period of time (35 days) induced by diverse agents, such as BSO or DEM, results in severe degeneration of intestinal mucosal epithelial cells (Martensson et al, 1990

In an adaptive response, alternative pathways, initiated by sterol-27 hydroxylase, play crucial roles in intestinal metabolism, cellular signaling, and microbial composition (Li and Chiang, 2014)

Mol Cell Neurosci 23(3):440450 Qian Z, Li Y, Guan Z, Guo P, Zheng K, Du Y, Yin S, Chen B, Wang H, Jiang J, Qiu K, Zhang M (2023) Global, regional, and national burden of multiple sclerosis from 1990 to 2019: findings of global burden of disease study 2019

Waszczak, K