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Discussion The Keap1-Nrf2-ARE signaling pathway is a major balancer of oxidative homeostasis, given its role in oxidative stress response but also physiological regulation 29

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While this may not be directly linked to the medication itself, it was unexpected

Interestingly, prominent hydrogen bonds, formed between the generated amine groups of Metro with the carbonyl oxygen of C P and the amine group of Metro-P3 with carbonyl oxygen of Ser54, provide a rationale for the inhibition of HpTpx red solely by the reduced ligands, explaining why the nitro-prodrugs cannot act as inhibitors of HpTpx