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We introduce four chemicals (PQ, rotenone, 6-OHDA, and MPTP/MPP+) that were applied to create the PD model for their capability to cause PD-like neuron impairments and symptoms (Figure 3)

The rate constants of physical quenching of 1 O 2 by -carotene and zeaxanthin were estimated to be 7 10 9 M 1 s 1 and of 7 10 8 M 1 s 1 for fucoxanthin, while the rate constants of chemical quenching for -carotene and zeaxanthin were approximately 4 10 6 M 1 s 1 and 3 10 5 M 1 s 1 for fucoxanthin [103]

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By dismantling these key suppressive networks, MDSC-focused strategies have the potential to broaden and deepen the responses to cancer immunotherapy and improve patient outcomes across a wide spectrum of malignancies