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GSSG is widely believed to be involved in the oxidation of PDI, but it has been shown that the ER flavoprotein Ero1 catalyses the oxidation of PDI in vivo and in vitro (Frand & Kaiser, 1998, 1999

Choi YJ, Lee J-E, Ji HD, Lee B-R, Lee SB, Kim KS, et al

This situation has been shown to lead to the onset and progression of various NCDs, including rheumatoid arthritis, Alzheimers disease (AD), and cancer