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Increased IF-Ab is seen in a patient with pernicious anemia

The phenotypic outcome is a shift toward higher energy expenditure and improved adipose/lipid profiles without the catabolic loss of lean tissue commonly seen with severe caloric restriction

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Paralleled well with the reduction of BAX expression, ALA treatment also significantly restored the protein level of Bcl-2 in which the hepatic Bcl-2 staining was successfully preserved in ALA-treated rats following CSD (Figures 6F,N)