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1 Detox Phase I: Bioactivation Phase I reactions are catalyzed by a number of different enzymes, primarily from the cytochrome P450 (CYP450) superfamily of enzymes

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In accounting for these findings, our own molecular modelling of the known sites for 4-HNE adduction within tubulin indicate that this form of modification is likely to cause both changes in the tertiary structure of the protein and importantly, alter the surface characteristics of the tubulin monomers

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