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Although acute insults such as smoking and diesel exhaust exposure initially increase GSH concentrations in the epithelial lining fluid (23, 46, 352), chronic insults such as long-term smoking over many years lead to increased airway GSSG formation and protein carbonylation (238)

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Comment: We received a comment in support of the increased applicable percentage of 26 percent for certain orphan drugs, which we finalized last year in the CY 2024 PFS final rule

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