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"While omega-3 fatty acids are crucial for our overall health, it's generally better for people with type 2 diabetes to get their intake by eating at least two portions of oily fish a week, than by taking supplements." But Dr Carrie Ruxton, from the industry-funded Health and Food Supplements Information Service (HSIS), said: "While I would prefer people to follow the government's advice and eat more fish, this isn't the reality and a daily omega-3 supplement - whether from fish oil or algae - can bridge the gap."

Factors such as diet, age, sex, and metabolic status have not been fully controlled

Considering the pivotal function of ferroptosis in OA, targets such as transient receptor potential vanilloid 1 (TRPV1) [27,28], glutathione peroxidase 4 (GPX4) [29], nuclear factor erythroid 2-related factor 2 (NRF2) [30], acyl-CoA synthetase long-chain family member 4 (ACSL4) [31], and nuclear coactivator adaptor 4 (NCOA4) [32] have surfaced as prospective regulators of ferroptosis and modulators of OA advancement

A study revealing marked clonal expansion of cytotoxic CD4 + T cells in Japanese supercentenarians expressing canonical cytotoxic effector molecules and transcriptional programmes resembling those of CD8 T cells, indicative of adaptive immune remodelling in exceptional longevity