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the term 'eicosanoid' includes many compounds that can either cause or prevent inflammation

The SASP is regulated by complex signaling networks, often involving transcription factors like NF-B and C/EBP, and can be reinforced by autocrine feedback loops involving factors like IL-1 [20]

Schwender K, Holtktter H, Johann KS, Glaub A, Schrenkamp M, Sibbing U, Banken S, Vennemann M, Pfeiffer H, Vennemann M, GeSID Study Group (2016) Sudden infant death syndrome: exposure to cigarette smoke leads to hypomethylation upstream of the growth factor independent 1 (GFI1) gene promoter

Studies have shown that the key enzyme responsible for producing TMA is choline TMA-lyase (CutC), which is a glycyl radical enzyme requiring the activating protein CutD to assist its function