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A precursor for cellular methylation reactions, methionine plays an important role in lipid metabolism, polyamine synthesis, immune function, heavy metal chelation, and maintenance of redox balance.4 Conversely, dietary methionine restriction in rodents increased energy expenditure, improved insulin resistance, and enhanced lipolysis and fatty acid oxidation in adipose tissue.5 The lipotropic effects of methionine may be attributed to its metabolite S-adenosyl methionine (SAM)

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By blocking NNMT, the compound is associated with preserved NAD+ levels and reduced fat storage, alongside improvements in cellular energy utilization and insulin sensitivity