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Various nanoparticles may help provide better targeting and drug delivery of metal complexes for multiple tumor models (Sharma et al., 2018)

Additionally, potential signaling pathways such as SIRT1, PI3K/Akt, and gene expression changes warrant deeper investigation

Circulating systemic serum glutathione appeared to be decreased in the old group compared to the young group, but the difference was not significance ( p -value: 0.1143)

In addition, GSTs are also involved in conferring multidrug resistance with a non-catalytic mechanism through their inhibition of the JNK signaling pathway, an event that protects tumoral cells from apoptosis, as it will be detailed later