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The findings indicated that Hua-Feng-Dan had a protective effect on the integrity of the intestinal barrier

On the one hand, activation of HIF-1 in osteoblasts has been shown to suppress osteoclastogenesis by upregulating osteoprotegerin (OPG) and interleukin-33 (IL-33), thereby inhibiting the RANKL/Notch1 signaling pathway (Kang et al., 2017)

This regulation alleviates oxidative damage, inflammatory responses, and mitochondrial dysfunction, thereby reducing neuronal death and enhancing the therapeutic efficacy in stroke (170)