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20 Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Conjugation with UDPGA via the SN2 reaction requires a nucleophile or handle on the drug or xenobioticSmith, Phase II Metabolism, UNC Chapel Hill, 8/2012 21 Stability of Glucuronide Conjugates VaryGlucuronides are excreted into bile, plasma and urine.Potential differences in glucuronide metabolites formed:i

postulated that individuals with lower GPx activity are predisposed to impaired antioxidant protection, which leads to oxidative damage to membrane fatty acid s and functional proteins (Fig

These will increase glutathione levels in the body which canlikewise renderthe treatments ineffective