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Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein

The DEGs were first screened based on a p_val_adj less than 0.05 (adjusted p-value, based on Bonferroni correction using all genes in the dataset) and an avg_log 2 FC above 0.4 (avg_log 2 FC: log fold-change of the average expression between PD and control groups

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220,223,224 Chaperone-mediated autophagy involves chaperone proteins recognizing and binding to specific protein sequences (KFERQ-like motifs), facilitating substrate transfer to lysosomes through interactions with lysosomal membrane proteins (LAMP2A)