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In a mouse model of hepatocellular carcinoma, regulatory T cells (Tregs) with high IGF-1R expression presented increased PI3K/AKT/mTOR signaling and were able to produce more ATP, lactate and ROS, which contribute to enhanced immunosuppressive effects (72)

Furthermore, APP/PS1 mice exhibit significant hyperactivity in the dorsal raphe nucleus during reward-seeking and motivational actions (Sakurai et al., 2020), indicating complex interactions between A pathology and neural circuitry affecting behavior

Tobin, D.M