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Eliezer, 2009

[163, 165] have reported that off-target toxicity in peripheral organs remained minimal, although they emphasised that excessively high doses or positively charged CQDs may still provoke ROS formation, mitochondrial dysfunction, or the activation of inflammatory pathways [163, 165]

Pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) expressed on epithelial cells interact with microbiota-derived pathogen-associated-molecular patterns (PAMPs) such as lipopolysaccharide (LPS) to activate myeloid differentiation factor 88 (MYD88)-dependent signaling

Mouse Lymphoma In the Biocompatibility Genotoxicity test, mouse lymphoma cells are used to determine whether a test material has the capacity to induce either point mutations or clastogenic (chromosomal breakage) events in a cultured mammalian cell line