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Therefore, APL is currently stratified into two categories: high-risk (WBC count 10 103/L) and low-risk (WBC count 5 103/L at diagnosis, suggesting that the results of treatment may be improved with the addition of maintenance in high-risk patients.47 On the other hand, some other trials questioned these findings, especially for those patients who achieved complete molecular response after consolidation phases.48 A meta-analysis published in 2013 assessed the role of maintenance in the treatment of APL in the first CR

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The samples were placed in boiling water for 5 min to terminate the reactions