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While the connection of the Jak-STAT pathway to antiviral defense may be indirect because of its general involvement in tolerance to tissue damage by the activation of repair mechanisms (232), recent research in shrimp and hemipteran insects confirms a more complicated picture in which the Jak-STAT pathway may function directly in the detection of pathogens (including viruses) for the activation of anti-bacterial or antiviral effector genes (233, 234)