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Critical role of CD44 in hepatotoxin-mediated liver injury

As the products of arachidonic acid metabolism such as leukotriene B4, 1-palmitoyl-2-oleoylsn- glycero-3-phosphocholine, 4-hydroxy-2-nonenal (4-HNE), 15S-HETE and 9/13- HODEs are potent ligands of peroxisome proliferator-activated receptor PPAR, PPAR/ and PPAR, the expression of these master regulators of lipid metabolism and inflammation were analyzed by Q-PCR

The onset of gallstones is associated with various factors, with several risk factors including aging, female gender, diabetes, rapid weight loss, metabolic syndrome, and gallbladder stasis [8,9,10]

On the other hand, clinical trials involving children and adolescent patients have mixed results (100)