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Furthermore, Figure 4D confirmed that H 2 O 2 increased the content of cellular ROS, while both targeting peptides obviously reduced the fluorescence intensity of the cellular ROS probe compared to that of GHK, especially RGD-GHK inhibited approximately 40% of ROS production

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This mechanism has direct relevance for post-surgical recovery, crush injuries, and any condition where vascular compromise threatens tissue viability

Research indicates that peptide-bound copper complexes may influence the local redox environment, potentially shaping how oxidative signals propagate within an organism