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Reviews of the rodent work note that the mechanism doesnt involve the hormonal suppression or receptor desensitization that would predict tolerance or rebound, and that adipose SAM levels tend to normalize rather than crash under inhibition

doi: 10.1016/j.bbadis.2022.166352 [DOI] [PMC free article] [PubMed] [Google Scholar] 213.Gaikwad S, Senapati S, Haque MA, Kayed R

Panda N, Desaraju S, Panigrahy RP, et al

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