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Furthermore, analysis of vertical activity revealed parallel findings (Fig

Human Trx and GSH systems have compensatory activities so that inhibition of one arm can be supplemented by the other 60 , suggesting that the inhibition of hTrxR by some of the compounds presented here will not be detrimental for humans as it is for schistosomes

We found that the five pockets have volumes ranging from 502 to 154 3 , displaying characteristics that lie between pocket-like invaginations and cavities (Supplementary Table 2)

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