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He was also interested in ascribing a physiological role to methylglyoxal

Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's disease

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Some people who take it in high doses (which can be necessary to correct a serious deficiency in vitamin B12 levels) may experience gastrointestinal symptoms like nausea, vomiting, and diarrhea