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10.1111/j.1445-5994.2011.02456.x Intern Med J

Rieger L, OShea S, Godsmark G, Stanicka J, Kelly G, OConnor R

Realizing this potential requires addressing critical gaps: although preclinical studies highlight innovative mechanisms (e.g., multimodal therapies and stimuli-responsive release), robust clinical validation remains scarce, necessitating phase I/II trials to confirm efficacy and safety

Figure 8 The regulatory function of HpaA is reminiscent of the activity of the gatekeeper protein YopN ( Yersinia outer protein N) from Yersinia spp., which inhibits T3E delivery when present in the cytoplasm (Iriarte et al., 1998