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Description

- Let the syringe reach room temperature

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Detailed protocol is described in Supplementary methods

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Anabolism is energetically costly and depends on metabolites that are also generated through catabolism, creating coupled feedback rather than a binary switch

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COMT o-methylates catechol oestrogen metabolites and mediates their detoxification, and it is plausible that the activity of this enzyme is inhibited by the accumulation of the cysteine precursor homocysteine

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