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Laboratory studies investigate how this peptide influences energy expenditure models, substrate utilization, and systemic metabolic responses

In further embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulates intracellular NAD+ levels to provide muscular therapy

Results Timeline and Expectations Understanding the realistic timeline for AOD-9604 effects helps set appropriate expectations and determine whether the peptide is producing its intended metabolic changes