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The cgas-cgamp-sting pathway of cytosolic DNA sensing and signaling

doi: 10.1038/s41422-020-00402-8 409 SoRelleEDDaiJReinoso-VizcainoNMBarryAPChanCLuftigMA

Evidence integration combined epidemiologic and animal toxicological evidence by considering various factors, such as the human relevance of animal findings, cross-stream coherence, susceptible populations, biological plausibility, mode of action, and supplemental mechanistic evidence

For example, zeaxanthin can be converted to violaxanthin, antheraxanthin, and neoxanthin through a series of enzyme-catalyzed reactions that are known as the xanthophyll cycle